Conclusion Hemoglobin was effectively encapsuled into alginate microspheres by improved electrostatic droplets generation, which would be a foundation not only for forming uniform controlled release membrane around the microsphere surface but also for preparing protein-loaded microspheres with size ≤ 10 μ m for oral administration. 结论采用静电液滴工艺实现了蛋白质在海藻酸盐微球中的高效包封,为在微球表面形成均匀控释膜、制备粒径≤10μm蛋白质药物的口服给药微球载体奠定了基础。